There are so many factors that come into play on this. How far is your realistic limit on taking that shot without magnification? (“Realistic” being the key word here.)
My eyes are bad enough at distance that 200 yards would be tough without magnification. Not sure I’d be able to see my target well enough. So for me, I’d be zeroing my muzzy at 100 yards and probably not going beyond 150 yards for a shot, and certainly not beyond 200 yards. I just can’t see that far anymore. My goal with a muzzy under new and current Utah regs would be to get under 100 yards for any shot. But that’s me, others may be able to do it differently. However, most probably can’t, realistically.