I have the same Leupold on my Rem 7MM Mag and it is a perfect set up with Hornady's Hevi Mag 139 gr SST & Interbond. Zero at 200 or 300 and on 14 power it is dead on the money in 100 yard increments. I have found a couple of other calibers/loads that I utilize that have basically the same trajectory and the scope works great on those rifles too. Hornady replaced Hevi Mag with Superformance which is almost identical in velocity, and when I run out of my Hevi Mag stock, I'll likely test their new load.
The ONLY problem you may encounter with the Varmit reticle on big game is finding the thin crosshairs when rushed in low light. This happened once to me in Idaho chasin' whitetails. At that moment, I was wishing for my Boone & Crockett reticle, which works better in that situation.
I have considered setting up a B&C reticle scope with a custom yardage dial, giving you a choice of using the B&C when in a hurry at decent range VS dialing in the yardage on a long shot with plenty of time at hand. This should be a great set up for any large game situation encountered.