I have been using the ELD-x with good luck, and accubonds with great luck.
I am not sure how many animals I have shot, but I think I can only remember 2 or 3 that got knocked down and did not get up.
If you think about it, a well placed shot through the lungs or the heart does not hit enough hard tissue to knock something over very often.
I shot an Antelope this year in Idaho, 325 yards 1 shot right through both lungs, straight up the front leg. 300 WSM with 180 Accubonds. He ran like the wind for 75 yards or so, then crashed like crazy...my point, that is enough gun to KNOCK down a tiny pronghorn, but it did not. I do not worry about KNOCK DOWN that much.