Unless you are fletching with the 5" vanes I dont see a problem with a 1 or 2 degree offset,2" to 4" vanes I know there won't be a problem unless your prongs are set really close on your rest,I have been fletching and shooting ofsets for years and have never had a problem with interference at all and have even shot 4" 4 fletch on my tm hunter rest as long as the prongs are not set too close,I usually set the prongs on my rest to cradle the arrow about 3/8 of the diameter,That usually has enough clearance between the prongs to clear everything I have ever fletched,I am currently using the 2" blazers with a 2 degree offset and they shoot great for me and I have no clearance problems at all, Fletch a couple arrows with the offset you have in mind and give them a go and see, If not its not that big a problem to strip them back off and go straight other than a few cents for the vanes and time.
Good Luck and hope it works out for ya,
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