I used the 165 Fed. Sierra Game King out of a 20" barrel at about 2650 fps. On mule deer at 217 it drilled right through creating a mess of the lungs and a fairly large exist wound.
I used the Federal Vital Shok with the 180 Nosler Partition out of the same rifle at about 2550, and at about 60 yards on a large bodied bull it drilled right through. Entry and exit where about the same size, fortunately it went through the shoulder and framentation of the bone did him in.
That's my limited experience.
Good luck,
Jim