My wife shoot the 270 and uses the 140 grain Hornady. She loves it. I can get her through 3/4 a box while practicing with no issues only the occasional pulled shot. My wife is tiny, weighs a 115 pounds soaking wet. The biggest issue we found was finding a gun that fit her right. Most guns the stock length was too much. We eventually got a a rem700, then had a gun smith cut the stock and add a pad. In all honesty it is a great gun.
IMHO there are many other thing you can do to lesson recoil effects that are way better than to give up bullet performance. A muzzy break, recoil pads etc.
Also when I started my wife, I told her that it was going to kick and the best she could do is just man up a bit. In the end it seemed a little harsh, but after some practice and fitment, she just accepts the fact recoils is part of the game. Practice and do everything to make her comfortable. Make sure she understands how to properly hold, shoulder and shoot the recoil will not be an issue... Of and for the 100 gr. bullets there is limited selection and they will not perform no where close to a 130gr bullet...