First, congrats on having an incredible wife!
Second, brown bears only don't go down easy when the hunter makes a less than great shot. Their skin is quite thin, and if you poke a hole in their heart they are DRT (study anatomy diagrams, you know the drill).
Third, out on the Alaska Peninsula (where I assume you'll be hunting based on the guide) expect wind. Lots of it. On my brown bear hunt I grossly underestimated the lateral drift from cross winds on a ~200 yard shot at a nice 9' boar on the 200gr bullet in my .300 Weatherby Mag. Had I been shooting my .270 with 130gr copper, I would likely have killed him instead of sending the bullet through the air in front of his face. Wind data for the location that I found after the fact showed average speeds of 50mph sustained that day with gusts up to 100mph. My wind drift was likely somewhere in the 20-40 inch range versus the 5-10 I had guesstimated.
Going forward my brown bear approach is going to be the .270 with 130gr copper, but having my .45-70 guide model on hand for follow up tracking with my dog if needed. I just hope I don't have to repeat the situation with my buddy's bear where Ravn Air didn't send our guns for a few days, leading to him using a borrowed rifle on his bear and my dog and I blood tracking it without so much as a knife on us while my buddy set up on the only high spot with the gun to attempt to cover us. Thankfully that bear flopped dead into the lake while my dog and I were still ~100yards away.